CD4⁺ T Cell-Released Extracellular Vesicles Potentiate the Efficacy of the HBsAg Vaccine by Enhancing B Cell Responses.

ABSTRACT: T cells secrete bioactive extracellular vesicles (EVs), but the potential biological effects of CD4⁺ T cell EVs are not clear. The main purpose of this study is to investigate the effects of CD4⁺ T cell-derived EVs on B cell responses and examine their role in antigen-mediated humoral immune responses. In this study, CD4⁺ T cell EVs are purified from activated CD4⁺ T cells in vitro. After immunization with the Hepatitis B surface antigen (HBsAg) vaccine, CD4⁺ T cell EVs-treated mice show stronger humoral immune responses, which is indicated by a greater Hepatitis B surface antibody (HBsAb) level in serum and a greater proportion of plasma cells in bone marrow. In addition, it is found that EVs released from activated CD4⁺ T

SUBMITTER: Lu J 

PROVIDER: S-EPMC6891927 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature