Inter-generational link of obesity in term and preterm births: role of maternal plasma acylcarnitines.

ABSTRACT:

Background/objectives

Acylcarnitines, intermediates of fatty acid oxidation, are known to be involved in obesity and insulin resistance. Since maternal prepregnancy overweight or obesity (OWO) is a recognized major risk factor for offspring OWO, we hypothesized that maternal plasma acylcarnitines may play a role in inter-generational OWO.

Subjects/methods

This study included 1402 mother-child pairs (1043 term, 359 preterm) recruited at birth from 1998-2013 and followed prospectively up to age 18 years at the Boston Medical Center. The primary outcomes were child OWO defined as BMI ≥ 85th percentile for age and sex. The primary exposures were maternal prepregnancy OWO defined as BMI ≥ 25 kg/m² and maternal acylcarnitine levels measured in plasma samples collected s

SUBMITTER: Wang G 

PROVIDER: S-EPMC6900290 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature