Associations of fat-soluble micronutrients and redox biomarkers with frailty status in the FRAILOMIC initiative.

ABSTRACT:

Background

A poor fat-soluble micronutrient (FMN) and a high oxidative stress status are associated with frailty. Our aim was to determine the cross-sectional association of FMNs and oxidative stress biomarkers [protein carbonyls (PrCarb) and 3-nitrotyrosine] with the frailty status in participants older than 65 years.

Methods

Plasma levels of vitamins A (retinol), D₃ , E (α-tocopherol and γ-tocopherol) and carotenoids (α-carotene and β-carotene, lycopene, lutein/zeaxanthin, and β-cryptoxanthin), PrCarb, and 3-nitrotyrosine were measured in 1450 individuals of the FRAILOMIC initiative. Participants were classified into robust, pre-frail, and frail using Fried's frailty criteria. Associations between biomarkers and frailty status were assessed by general linear and

SUBMITTER: Kochlik B 

PROVIDER: S-EPMC6903435 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature