MiR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation.

ABSTRACT: Follicular helper T (T_FH) cells are essential for generating protective humoral immunity. To date, microRNAs (miRNAs) have emerged as important players in regulating T_FH cell biology. Here, we show that loss of miR-23~27~24 clusters in T cells resulted in elevated T_FH cell frequencies upon different immune challenges, whereas overexpression of this miRNA family led to reduced T_FH cell responses. Mechanistically, miR-23~27~24 clusters coordinately control T_FH cells through targeting a network of genes that are crucial for T_FH cell biology. Among them, thymocyte selection-associated HMG-box protein (TOX) was identified as a central transcription regulator in T_FH cell development. TOX is highly up-regulated in both m

SUBMITTER: Wu CJ 

PROVIDER: S-EPMC6905868 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature