Sclerostin-Neutralizing Antibody Enhances Bone Regeneration Around Oral Implants.

ABSTRACT:

Background

Dental implants are an important option for replacement of missing teeth. A major clinical challenge is how best to accelerate bone regeneration and reduce the healing time for functional restoration after implant placement. A sclerostin-neutralizing antibody (Scl-Ab) has been shown to enhance alveolar bone formation and fracture repair. The aim of this study was to investigate the effects of systemic administration of Scl-Ab on dental implant osseointegration and bone regeneration in an experimental alveolar ridge tooth extraction model.

Materials and methods

To investigate the effects of Scl-Ab on bone regeneration and dental implant osseointegration, an experimental alveolar bone osteotomy rat model was adopted. One month after extraction of maxillary right fir

SUBMITTER: Yu SH 

PROVIDER: S-EPMC6916116 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature