Establishment and assessment of the hepatic venous pressure gradient using biofluid mechanics (HVPG_BFM): protocol for a prospective, randomised, non-controlled, multicentre study.

ABSTRACT:

Introduction

Portal hypertension (PH) is a severe disease with a poor outcome. Hepatic venous pressure gradient (HVPG), the current gold standard to detect PH, is available only in few hospitals due to its invasiveness and technical difficulty. This study aimed to establish and assess a novel model to calculate HVPG based on biofluid mechanics.

Methods and analysis

This is a prospective, randomised, non-controlled, multicentre trial. A total of 248 patients will be recruited in this study, and each patient will undergo CT, blood tests, Doppler ultrasound and HVPG measurement. The study consists of two independent and consecutive cohorts: original cohort (124 patients) and validation cohort (124 patients). The researchers will establish and improve the HVPG using biofluid mec

SUBMITTER: Lin JY 

PROVIDER: S-EPMC6926408 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature