Multiple sclerosis relapse risk in the postoperative period: Effects of invasive surgery and anesthesia.

ABSTRACT:

Background

Postoperative multiple sclerosis (MS) relapses are a concern among patients and providers.

Objective

To determine whether MS relapse risk is higher postoperatively.

Methods

Data were extracted from medical records of MS patients undergoing surgery at a tertiary center (2000-2016). Conditional logistic regression estimated within-patient unadjusted and age-adjusted odds of postoperative versus preoperative relapse.

Results

Among 281 patients and 609 surgeries, 12 postoperative relapses were identified. The odds of postoperative versus preoperative relapse in unadjusted (odds ratio (OR) = 0.56, 95% confidence interval (CI) = 0.18-1.79; p = 0.33) or age-adjusted models (OR = 0.66, 95% CI = 0.20-2.16; p = 0.49) were not increased.

Conclusions

Surgery/anesthesia exposure did not increase postoperative relapse risk. These findings require confirmation in larger studies.

SUBMITTER: De Lott LB 

PROVIDER: S-EPMC6930348 | biostudies-literature |

REPOSITORIES: biostudies-literature