Prognostic value of immune cells in the tumor microenvironment of early-stage lung cancer: a meta-analysis.

ABSTRACT:

Background

Early-stage non-small cell lung cancer (NSCLC) patients carry significant risk of recurrence post-surgery. In-depth characterization of the immune tumor microenvironment (TME) can have prognostic value. This study aimed to evaluate the association of individual immune cell types in the TME with clinical outcomes in surgically resected, early-stage NSCLC.

Methods

We performed a systematic literature search of the National Library of Medicine database through November 2019, investigating predefined biomarkers (CD3+ T cells, CD4+ T helper cells, CD8+ cytotoxic T cells, CD20+ B cells, CD56+ & CD57+ Natural Killer (NK) cells, CD68+ Tissue Associated Macrophages (TAMS), FoxP3+ T regulatory cells, and Mast Cells (MC)), and their association with survival following PRISMA

SUBMITTER: Tuminello S 

PROVIDER: S-EPMC6935257 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature