Response to Reduced Nicotine Content in Vulnerable Populations: Effect of Menthol Status.

ABSTRACT:

Objectives

In this study, we investigated potential effects of being a menthol smoker on response to reduced nicotine content (RNC) cigarettes in smokers especially vulnerable to smoking.

Method

Participants were 169 smokers (61 menthol and 108 non-menthol smokers) with comorbid mental illness, substance use disorder, or socioeconomic disadvantage. Participants completed a double-blind study assessing addiction potential, withdrawal/craving, and compensatory smoking across 4 research cigarettes varying in nicotine content from very low levels to commercial levels (0.4, 2.4, 5.2, 15.8mg/g of tobacco). Repeated measures analysis of variance was used to examine potential moderating effects of menthol status.

Results

Statistically significant effects of nicotine dose were

SUBMITTER: Davis DR 

PROVIDER: S-EPMC6936762 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature