Cardiovascular Events Among Adults Treated With Chimeric Antigen Receptor T-Cells (CAR-T).

ABSTRACT:

Background

Chimeric antigen receptors redirect T cells (CAR-T) to target cancer cells. There are limited data characterizing cardiac toxicity and cardiovascular (CV) events among adults treated with CAR-T.

Objectives

The purpose of this study was to evaluate the possible cardiac toxicities of CAR-T.

Methods

The registry included 137 patients who received CAR-T. Covariates included the occurrence and grade of cytokine release syndrome (CRS) and the administration of tocilizumab for CRS. Cardiac toxicity was defined as a decrease in the left ventricular ejection fraction or an increase in serum troponin. Cardiovascular events were a composite of arrhythmias, decompensated heart failure, and CV death.

Results

The median age was 62 years (interquartile range [IQR]:

SUBMITTER: Alvi RM 

PROVIDER: S-EPMC6938409 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature