MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort.

ABSTRACT:

Background

Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls.

Methods

In this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre coh

SUBMITTER: Pellegrini C 

PROVIDER: S-EPMC6942319 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature