The specific ex vivo released cytokine profile is associated with ischemic stroke outcome and improves its prediction.

ABSTRACT: BACKGROUND:Inflammation is associated with poor outcome after stroke. A relationship between ex vivo cytokine synthesis and stroke outcome remains unclear. We explored an association between ex vivo cytokine release, circulating interleukin (IL)-6 as a marker of systemic inflammation, and stroke prognosis. We assessed the utility of ex vivo synthesized cytokines for predicting stroke outcome. METHODS:We collected blood from 248 ischemic stroke patients and stimulated it ex vivo with lipopolysaccharide. We measured concentration of synthesized cytokines (TNFα, IP-10, IL-1β, IL-6, IL-8, IL-10, and IL-12) and plasma IL-6. We assessed functional outcome 3 months after stroke using the modified Rankin Scale. To assess the prognostic ability of cytokines, we applied multivariate logistic regress

SUBMITTER: Klimiec-Moskal E 

PROVIDER: S-EPMC6945431 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature