Overexpression of CD6 and PD-1 Identifies Dysfunctional CD8+ T-Cells During Chronic SIV Infection of Rhesus Macaques.

ABSTRACT: Effective CD8+ T-cell responses play an important role in determining the course of SIV/HIV viral infection. Here we identified a unique population of dysfunctional CD8+ T-cells in lymphoid tissues and bronchoalveolar lavage (BAL) of rhesus macaques with chronic SIV infection characterized by co-expression of CD6 and PD-1. The frequency of CD6 and PD-1 co-expressing CD8+ T-cells was significantly increased in lymphoid tissues and BAL during chronic SIV infection compared to pre-infection levels. These CD6+PD-1+CD8+ T-cells displayed impaired proliferation, cytokine secretion and cytotoxicity compared to their CD6-PD-1+CD8+ T cell counterparts. The frequency of CD8+PD-1+ and CD8+CD6-PD-1+ T-cells in the lymph node and bone marrow did not correlate with SIV viral load, whereas the frequency

SUBMITTER: Enyindah-Asonye G 

PROVIDER: S-EPMC6961594 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature