Estimating associations between antidepressant use and incident mild cognitive impairment in older adults with depression.

ABSTRACT:

Introduction

Previous studies have provided equivocal evidence of antidepressant use on subsequent cognitive impairment; this could be due to inconsistent modeling approaches. Our goals are methodological and clinical. We evaluate the impact of statistical modeling approaches on the associations between antidepressant use and risk of Mild Cognitive Impairment (MCI) in older adults with depression.

Methods

716 participants were enrolled. Our primary analysis employed a time-dependent Cox proportional hazards model. We also implemented two fixed-covariate proportional hazards models-one based on having ever used antidepressants during follow-up, and the other restricted to baseline use only.

Results

Treating antidepressant use as a time-varying covariate, we found no si

SUBMITTER: Han F 

PROVIDER: S-EPMC6968868 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature