Midkine-a Is Required for Cell Cycle Progression of Muller Glia during Neuronal Regeneration in the Vertebrate Retina.

ABSTRACT: In the retina of zebrafish, Müller glia have the ability to reprogram into stem cells capable of regenerating all classes of retinal neurons and restoring visual function. Understanding the cellular and molecular mechanisms controlling the stem cell properties of Müller glia in zebrafish may provide cues to unlock the regenerative potential in the mammalian nervous system. Midkine is a cytokine/growth factor with multiple roles in neural development, tissue repair, and disease. In midkine-a loss-of-function mutants of both sexes, Müller glia initiate the appropriate reprogramming response to photoreceptor death by increasing expression of stem cell-associated genes, and entering the G1 phase of the cell cycle. However, transition from G1 to S phase is blocked in the absence of Midkine-a, r

SUBMITTER: Nagashima M 

PROVIDER: S-EPMC7002140 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature