Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection.

ABSTRACT: Immunopathogenesis in systemic viral infections can induce a septic state with leaky capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment options. Murine gammaherpesvirus-68 (MHV-68) intraperitoneal infection is a gammaherpesvirus model for producing severe vasculitis, colitis and lethal hemorrhagic pneumonia in interferon gamma receptor-deficient (IFNγR^-/-) mice. In prior work, treatment with myxomavirus-derived Serp-1 or a derivative peptide S-7 (G₃₀₅TTASSDTAITLIPR₃₁₉) induced immune protection, reduced disease severity and improved survival after MHV-68 infection. Here, we investigate the gut bacterial microbiome in MHV-68 infection. Antibiotic suppression markedly accelerated MHV-68 pathology causing pulmonary consoli

SUBMITTER: Yaron JR 

PROVIDER: S-EPMC7012916 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature