Voxel-based analysis of gray matter relaxation rates shows different correlation patterns for cognitive impairment and physical disability in relapsing-remitting multiple sclerosis.

ABSTRACT:

Background

Regional analyses of markers of microstructural gray matter (GM) changes, including relaxation rates, have shown inconsistent correlations with physical and cognitive impairment in MS.

Objective

To assess voxelwise the correlation of the R1 and R2 relaxation rates with the physical and cognitive impairment in MS.

Methods

GM R1 and R2 relaxation rate maps were obtained in 241 relapsing-remitting MS patients by relaxometric segmentation of MRI studies. Correlations with the Expanded Disability Status Scale (EDSS) and the percentage of impaired cognitive test (Brief Repeatable Battery and Stroop Test, available in 186 patients) were assessed voxelwise, including voxel GM content as nuisance covariate to remove the effect of atrophy on the correlations.

Resu

SUBMITTER: Cassiano MT 

PROVIDER: S-EPMC7025083 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature