Genetic risk, adherence to a healthy lifestyle, and type 2 diabetes risk among 550,000 Chinese adults: results from 2 independent Asian cohorts.

ABSTRACT:

Background

Whether genetic susceptibility to type 2 diabetes is modified by a healthy lifestyle among Chinese remains unknown.

Objectives

The aim of the study was to determine whether genetic risk and adherence to a healthy lifestyle contribute independently to the risk of developing type 2 diabetes.

Methods

We defined a lifestyle score using BMI, alcohol intake, smoking, physical activities, and diets in 461,030 participants from the China Kadoorie Biobank and 38,434 participants from the Singapore Chinese Health Study. A genetic risk score was constructed based on type 2 diabetes loci among 100,175 and 16,172 participants in each cohort, respectively. A Cox proportional-hazards model was used to estimate the interaction between genetic and lifestyle factors on the r

SUBMITTER: Li H 

PROVIDER: S-EPMC7049535 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature