Genetic factors, adherence to healthy lifestyle behaviors, and risk of bladder cancer.

ABSTRACT:

Background

Genetic and lifestyle factors both contribute to the pathogenesis of bladder cancer, but the extent to which the increased genetic risk can be mitigated by adhering to a healthy lifestyle remains unclear. We aimed to investigate the association of combined lifestyle factors with bladder cancer risk within genetic risk groups.

Methods

We conducted a prospective study of 375 998 unrelated participants of European ancestry with genotype and lifestyle data and free of cancer from the UK biobank. We generated a polygenic risk score (PRS) using 16 single nucleotide polymorphisms and a healthy lifestyle score based on body weight, smoking status, physical activity, and diet. Cox models were fitted to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of

SUBMITTER: He Q 

PROVIDER: S-EPMC10568887 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature