Thermal distribution, physiological effects and toxicities of extracorporeally induced whole-body hyperthermia in a pig model.

ABSTRACT:

Background

Extracorporeally induced whole-body hyperthermia (eWBH) might be a beneficial treatment in cancer patients. Objectives of this pig study were to assess thermal distribution, (patho-)physiological effects, and safety of eWBH with a new WBH device.

Methods

Fourteen healthy adult pigs were anesthetized, mechanically ventilated, and cannulated; 12 were included in the analysis. Blood was heated in 11 pigs (one pig served as control) using a WBH device (Vithèr Hyperthermia B.V.) containing two separate fluidic circuits and a heat exchanger. Temperature was monitored on nine different sites, including the brain. Core temperature (average of 4 deep probes) was elevated to 42°C for 2 hr.

Results

Elevation of core body temperature to 42°C took on average (± standard

SUBMITTER: Lassche G 

PROVIDER: S-EPMC7058172 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature