Dataset Information

CD28 and CD57 define four populations with distinct phenotypic properties within human CD8⁺ T cells.

ABSTRACT: After repeated antigen exposure, both memory and terminally differentiated cells can be generated within CD8⁺ T cells. Although, during their differentiation, activated CD8⁺ T cells may first lose CD28, and CD28^- cells may eventually express CD57 as a subsequent step, a population of CD28⁺ CD57⁺ (DP) CD8⁺ T cells can be identified in the peripheral blood. How this population is distinct from CD28^- CD57^- (DN) CD8⁺ T cells, and from the better characterized non-activated/early-activated CD28⁺ CD57^- and senescent-like CD28^- CD57⁺ CD8⁺ T cell subsets is currently unknown. Here, RNA expression of the four CD8⁺ T cell subsets isolate

SUBMITTER: Pangrazzi L

PROVIDER: S-EPMC7079235 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Dataset Information

CD28 and CD57 define four populations with distinct phenotypic properties within human CD8⁺ T cells.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

CD28 and CD57 define four populations with distinct phenotypic properties within human CD8+ T cells.

OmicsDI is part of the ELIXIR infrastructure

Tweets

CD28 and CD57 define four populations with distinct phenotypic properties within human CD8⁺ T cells.