The glutamic acid-rich-long C-terminal extension of troponin T has a critical role in insect muscle functions.

ABSTRACT: The troponin complex regulates the Ca²⁺ activation of myofilaments during striated muscle contraction and relaxation. Troponin genes emerged 500-700 million years ago during early animal evolution. Troponin T (TnT) is the thin-filament-anchoring subunit of troponin. Vertebrate and invertebrate TnTs have conserved core structures, reflecting conserved functions in regulating muscle contraction, and they also contain significantly diverged structures, reflecting muscle type- and species-specific adaptations. TnT in insects contains a highly-diverged structure consisting of a long glutamic acid-rich C-terminal extension of ∼70 residues with unknown function. We found here that C-terminally truncated Drosophila TnT (TpnT-CD70) retains binding of tropomyosin, troponin I, and t

SUBMITTER: Cao T 

PROVIDER: S-EPMC7086023 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature