Blood glucose and insulin concentrations after alpha-2-agonists administration in horses with and without insulin dysregulation.

ABSTRACT:

Background

In metabolically stable horses, alpha-2-agonists suppress insulin secretion with transient hyperglycemia and rebound hyperinsulinemia. In horses with insulin dysregulation (ID), the effect of alpha-2-agonists has not been investigated; however, both the alpha-2-agonist-induced suppression of insulin secretion and rebound hyperinsulinemia could have clinical relevance.

Hypothesis/objectives

In horses with ID, alpha-2-agonists will alter insulin and glucose dynamics.

Animals

Seven horses with ID and 7 control horses.

Methods

In this randomized crossover study, xylazine hydrochloride (1.1 mg/kg) or detomidine hydrochloride (30 μg/kg) were administered IV, and blood was collected for glucose and insulin concentrations at 0, 15, 30, 45, 60, 90, 120, 150,

SUBMITTER: Kritchevsky JE 

PROVIDER: S-EPMC7096659 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature