Characterization of bone aluminum, a potential biomarker of cumulative exposure, within an occupational population from Zunyi, China.

ABSTRACT:

Objectives

Aluminum (Al) is a neurotoxicant; however, efforts to understand Al toxicity are limited by the lack of a quantitative biomarker of cumulative exposure. Bone Al measurements may address this need. Here, we describe and compare non-invasive bone Al measurements with fingernail Al and Al cumulative exposure indices (CEIs).

Methods

We completed a cross-sectional study of 43 factory workers in Zunyi, China. Bone Al measurements were taken with a compact in-vivo neutron activation analysis system (IVNAA). Fingernail samples were analyzed using inductively coupled plasma mass spectrometry. CEIs, based on self-reported work history and prior literature, were calculated for the prior 5, 10, 15, 20 years and lifetime work history. Linear regressions adjusted for age and ed

SUBMITTER: Hasan Z 

PROVIDER: S-EPMC7112220 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature