Quantum modelling and molecular docking evaluation of some selected quinoline derivatives as anti-tubercular agents.

ABSTRACT: Mycobacterium tuberculosis has instigated a serious challenge toward the effective treatment of tuberculosis. The reoccurrence of the resistant strains of the disease to accessible drugs/medications has mandate for the development of more effective anti-tubercular agents with efficient activities. Time expended and costs in discovering and synthesizing new hypothetical drugs with improved biological activity have been a major challenge toward the treatment of multi-drug resistance strain M. tuberculosis (TB). Meanwhile, to solve the problem stated, a new approach i.e. QSAR which establish connection between novel drugs with a better biological against M. tuberculosis is adopted. The anti-tubercular model established in this study to forecast the biological activities of some anti-tubercula

SUBMITTER: Adeniji SE 

PROVIDER: S-EPMC7114754 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature