Ontology highlight
ABSTRACT:
SUBMITTER: Vrubliauskas D
PROVIDER: S-EPMC7124983 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20200225 15
A novel Co<sup>II</sup> -catalyzed polyene cyclization was developed that is uniquely effective when performed in hexafluoroisopropanol as the solvent. The process is presumably initiated by metal-catalyzed hydrogen-atom transfer (MHAT) to 1,1-disubstituted or monosubstituted alkenes, and the reaction is remarkable for its tolerance of internal alkenes bearing either electron-rich methyl or electron-deficient nitrile substituents. Electron-rich aromatic terminators are required in both cases. Te ...[more]