Organozinc pivalates for cobalt-catalyzed difluoroalkylarylation of alkenes.

ABSTRACT: Installation of fluorine into pharmaceutically relevant molecules plays a vital role in their properties of biology or medicinal chemistry. Direct difunctionalization of alkenes and 1,3-dienes to achieve fluorinated compounds through transition-metal catalysis is challenging, due to the facile β-H elimination from the Csp³‒[M] intermediate. Here we report a cobalt-catalyzed regioselective difluoroalkylarylation of both activated and unactivated alkenes with solid arylzinc pivalates and difluoroalkyl bromides through a cascade Csp³‒Csp³/Csp³‒Csp² bond formation under mild reaction conditions. Indeed, a wide range of functional groups on difluoroalkyl bromides, olefins, 1,3-dienes as well as (hetero)arylzinc pivalates are well tolerated

SUBMITTER: Cheng X 

PROVIDER: S-EPMC8285467 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature