Annexin V⁺ Microvesicles in Children and Adolescents with Type 1 Diabetes: A Prospective Cohort Study.

ABSTRACT:

Background

Type 1 diabetes is a chronic disease including hyperglycemia and accelerated atherosclerosis, with high risk of micro- and macrovascular complications. Circulating microvesicles (cMVs) are procoagulant cell fragments shed during activation/apoptosis and discussed to be markers of vascular dysfunction and hypercoagulability. Limited knowledge exists on hypercoagulability in young diabetics. We aimed to investigate cMVs over a five-year period in children/adolescents with type 1 diabetes compared with controls and any associations with glycemic control and cardiovascular risk factors. We hypothesized increased shedding of cMVs in type 1 diabetes in response to vascular activation.

Methods

The cohort included type 1 diabetics (n = 40) and healthy controls (

SUBMITTER: Bratseth V 

PROVIDER: S-EPMC7149325 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature