A signature of 33 immune-related gene pairs predicts clinical outcome in hepatocellular carcinoma.

ABSTRACT:

Objective

Hepatocellular carcinoma (HCC) has become the second most common tumor type that contributes to cancer-related death worldwide. The study aimed to establish a robust immune-related gene pair (IRGP) signature for predicting the prognosis of HCC patients.

Methods

Two RNA-seq datasets (The Cancer Genome Atlas Program and International Cancer Genome Consortium) and one microarray dataset (GSE14520) were included in this study. We used a series of immune-related genes from the ImmPort database to construct gene pairs. Lasso penalized Cox proportional hazards regression was employed to develop the best prognostic signature. We assigned patients into two groups with low immune risk and high immune risk. Then, the prognostic ability of the signature was evaluated by a log-

SUBMITTER: Sun XY 

PROVIDER: S-EPMC7163092 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature