Acute exposure to air pollution is associated with novel changes in blood levels of endothelin-1 and circulating angiogenic cells in young, healthy adults.

ABSTRACT: Acute and chronic exposures to particulate matter (PM_2.5) air pollution increase the risk for cardiovascular disease (CVD). A hypothesized mechanism linking PM_2.5 exposure and CVD is the induction of endothelial dysfunction - a key step to increased CVD risk. Although PM_2.5 exposure is associated with endothelial dysfunction and the vasoconstrictor peptide endothelin-1 (ET-1) is upregulated in endothelial dysfunction, the effects of PM_2.5 on ET-1 and whether or not ET-1 mediates the downstream effects of PM_2.5 are unclear. In addition to examining associations between acute changes in ambient PM_2.5 and circulating levels of ET-1, we also looked at whether changes in ET-1 were associated with changes in markers of vascular he

SUBMITTER: Finch J 

PROVIDER: S-EPMC7164546 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature