Pregenual or subgenual anterior cingulate cortex as potential effective region for brain stimulation of depression.

ABSTRACT:

Background

The dorsolateral prefrontal cortex (DLPFC) is the standard stimulation target for the repetitive transcranial magnetic stimulation (rTMS) treatment of major depression disorder (MDD). A retrospective study by Fox and colleagues found that a more negative resting-state functional magnetic resonance imaging (RS-fMRI) functional connectivity (FC) between left DLPFC and the subgenual anterior cingulate cortex (sgACC) in a large group of healthy participants is associated with a better curative effects of rTMS in MDD, suggesting that the sgACC may be an effective region. However, a recent meta-analysis on RS-fMRI studies found that the pregenual ACC (pgACC), rather than the sgACC, of MDD patients showed increased local activity.

Methods

We used the stimulation coordina

SUBMITTER: Jing Y 

PROVIDER: S-EPMC7177590 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature