Ontology highlight
ABSTRACT:
SUBMITTER: Bader AS
PROVIDER: S-EPMC7181826 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Bader Aldo S AS Bushell Martin M
Cell death & disease 20200424 4
The recent discovery of DNA:RNA hybrids, or R-loops, actively forming at DNA double-strand breaks (DSBs) has unlocked fresh insight into how RNA participates in DNA repair. However, the manner of DSB-induced R-loop formation is vital in determining its mechanism of action and is currently under debate. Here, we analyse published DNA:RNA-hybrid sequencing to elucidate the features that determine DSB-induced R-loop formation. We found that pre-existing transcriptional activity was critical for R-l ...[more]