Omega-3 vs. omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation.

ABSTRACT:

Objective

To compare the effects of a conventional omega-6 lipid infusion and a fish oil based (omega-3) lipid infusion for parenteral nutrition on neutrophil function, lipid mediators, and plasma free fatty acids.

Design and setting

Open-label, randomized, pilot study in a university hospital medical intensive care unit and experimental laboratory.

Patients and participants

Ten patients with septic shock and eight healthy controls.

Interventions

Patients (five per group) requiring parenteral nutrition received intravenously either a omega-3 or a omega-6 lipid emulsion for a 10-day period.

Measurements and results

At baseline levels of plasma free fatty acids were elevated several-fold, including high concentrations of the omega-6 lipid precursor arachid

SUBMITTER: Mayer K 

PROVIDER: S-EPMC7187949 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature