Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues.
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ABSTRACT:
SUBMITTER: Marderstein AR
PROVIDER: S-EPMC7200670 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues.
Marderstein Andrew R AR Uppal Manik M Verma Akanksha A Bhinder Bhavneet B Tayyebi Zakieh Z Mezey Jason J Clark Andrew G AG Elemento Olivier O
Nature communications 20200505 1
Despite infiltrating immune cells having an essential function in human disease and patients' responses to treatments, mechanisms influencing variability in infiltration patterns remain unclear. Here, using bulk RNA-seq data from 46 tissues in the Genotype-Tissue Expression project, we apply cell-type deconvolution algorithms to evaluate the immune landscape across the healthy human body. We discover that 49 of 189 infiltration-related phenotypes are associated with either age or sex (FDR < 0.1) ...[more]
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