Calprotectin as a New Sensitive Marker of Neutrophilic Inflammation in Patients with Bronchiolitis Obliterans.

ABSTRACT:

Introduction

Bronchiolitis obliterans (BO) is a chronic disease in which persistent inflammation leads to obstruction and obliteration of the small airways. The aim of this study was to evaluate the value of calprotectin as an inflammatory marker in induced sputum.

Methods

Twenty-eight patients suffering from BO and 18 healthy controls were examined. Lung function was measured by spirometry, body plethysmography, and lung clearance index (LCI). The induced sputum was obtained, cell counts were performed, and cytokines were measured using cytometric bead array (CBA). Calprotectin was quantified in the sputum and serum samples using commercially available sandwich ELISA.

Results

Spirometry parameters including forced vital capacity (FVC), forced expiratory volume in 1 s

SUBMITTER: Jerkic SP 

PROVIDER: S-EPMC7211255 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature