Gliomas display distinct sex-based differential methylation patterns based on molecular subtype.

ABSTRACT:

Background

Gliomas are the most common type of primary brain tumor and one of many cancers where males are diagnosed with greater frequency than females. However, little is known about the sex-based molecular differences in glioblastomas (GBMs) or lower grade glioma (non-GBM) subtypes. DNA methylation is an epigenetic mechanism involved in regulating gene transcription. In glioma and other cancers, hypermethylation of specific gene promoters downregulates transcription and may have a profound effect on patient outcome. The purpose of this study was to determine if sex-based methylation differences exist in different glioma subtypes.

Methods

Molecular and clinical data from glioma patients were obtained from The Cancer Genome Atlas and grouped according to tumor grade and mol

SUBMITTER: Johansen ML 

PROVIDER: S-EPMC7212920 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature