Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.

ABSTRACT: This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.

SUBMITTER: Umuhire Juru A 

PROVIDER: S-EPMC7218690 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature