Heterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinoma.

ABSTRACT: Despite the success of monotherapies based on blockade of programmed cell death 1 (PD-1) in human melanoma, most patients do not experience durable clinical benefit. T-cell infiltration and/or the presence of PD-L1 in tumors may be used as indicators of clinical response; However, recent studies reported that preexisting tumor-specific T cells may have limited reinvigoration capacity. Therefore, evaluating status of T cells of tumor-adjacent area and its impact on the prognosis are very important. Here, we examined 117 surgical samples from HCC patients for infiltration of exhausted T cell (Tex) including CD4⁺-Tex, CD8⁺-Tex and regulatory T cell (FOXP3⁺-Treg) in tumor and adjacent tissue. CD3⁺CD45RO⁺T cells were sorted from adjacent ar

SUBMITTER: Liu F 

PROVIDER: S-EPMC7219269 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature