The IL-33-induced p38-/JNK1/2-TNF? axis is antagonized by activation of ?-adrenergic-receptors in dendritic cells.
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ABSTRACT:
SUBMITTER: Helbig C
PROVIDER: S-EPMC7235212 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
The IL-33-induced p38-/JNK1/2-TNFα axis is antagonized by activation of β-adrenergic-receptors in dendritic cells.
Helbig Christiane C Weber Franziska F Andreas Nico N Herdegen Thomas T Gaestel Matthias M Kamradt Thomas T Drube Sebastian S
Scientific reports 20200518 1
IL-33, an IL-1 cytokine superfamily member, induces the activation of the canonical NF-κB signaling, and of Mitogen Activated Protein Kinases (MAPKs). In dendritic cells (DCs) IL-33 induces the production of IL-6, IL-13 and TNFα. Thereby, the production of IL-6 depends on RelA whereas the production of IL-13 depends on the p38-MK2/3 signaling module. Here, we show that in addition to p65 and the p38-MK2/3 signaling module, JNK1/2 are essential for the IL-33-induced TNFα production. The central r ...[more]
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