Dataset Information

SJS/TEN 2019: From science to translation.

ABSTRACT: Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are potentially life-threatening, immune-mediated adverse reactions characterized by widespread erythema, epidermal necrosis, and detachment of skin and mucosa. Efforts to grow and develop functional international collaborations and a multidisciplinary interactive network focusing on SJS/TEN as an uncommon but high burden disease will be necessary to improve efforts in prevention, early diagnosis and improved acute and long-term management. SJS/TEN 2019: From Science to Translation was a 1.5-day scientific program held April 26-27, 2019, in Vancouver, Canada. The meeting successfully engaged clinicians, researchers, and patients and conducted many productive discussions on research and patient care needs.

SUBMITTER: Chang WC

PROVIDER: S-EPMC7261636 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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SJS/TEN 2019: From science to translation.

Chang Wan-Chun WC Abe Riichiro R Anderson Paul P Anderson Wanpen W Ardern-Jones Michael R MR Beachkofsky Thomas M TM Bellón Teresa T Biala Agnieszka K AK Bouchard Charles C Cavalleri Gianpiero L GL Chapman Nicole N Chodosh James J Choi Hyon K HK Cibotti Ricardo R RR Divito Sherrie J SJ Dewar Karen K Dehaeck Ulrike U Etminan Mahyar M Forbes Diane D Fuchs Esther E Goldman Jennifer L JL Holmes James H JH Hope Elyse A EA Hung Shuen-Iu SI Hsieh Chia-Ling CL Iovieno Alfonso A Jagdeo Julienne J Kim Mee Kum MK Koelle David M DM Lacouture Mario E ME Le Pallec Sophie S Lehloenya Rannakoe J RJ Lim Robyn R Lowe Angie A McCawley Jean J McCawley Julie J Micheletti Robert G RG Mockenhaupt Maja M Niemeyer Katie K Norcross Michael A MA Oboh Douglas D Olteanu Cristina C Pasieka Helena B HB Peter Jonathan J Pirmohamed Munir M Rieder Michael M Saeed Hajirah N HN Shear Neil H NH Shieh Christine C Straus Sabine S Sukasem Chonlaphat C Sung Cynthia C Trubiano Jason A JA Tsou Sheng-Ying SY Ueta Mayumi M Volpi Simona S Wan Chen C Wang Hongsheng H Wang Zhao-Qing ZQ Weintraub Jessica J Whale Cindy C Wheatley Lisa M LM Whyte-Croasdaile Sonia S Williams Kristina B KB Wright Galen G Yeung Sonia N SN Zhou Li L Chung Wen-Hung WH Phillips Elizabeth J EJ Carleton Bruce C BC

Journal of dermatological science 20200307 1

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are potentially life-threatening, immune-mediated adverse reactions characterized by widespread erythema, epidermal necrosis, and detachment of skin and mucosa. Efforts to grow and develop functional international collaborations and a multidisciplinary interactive network focusing on SJS/TEN as an uncommon but high burden disease will be necessary to improve efforts in prevention, early diagnosis and improved acute and long-term m ...[more]

PMID: 32192826

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Project description:BackgroundStevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), caused by allopurinol therapy, are strongly associated with the human leukocyte antigen (HLA), HLA-B*5801. Identification of HLA-B*5801 genotype before prescribing allopurinol offers the possibility of avoiding allopurinol-induced SJS/TEN. As there is a paucity of evidence about economic value of such testing, this study aims to determine the cost-effectiveness of HLA-B*5801 testing compared with usual care (no genetic testing) before allopurinol administration in Thailand.Methods and findingA decision analytical and Markov model was used to estimate life time costs and outcomes represented as quality adjusted life years (QALYs) gained. The model was populated with relevant information of the association between gene and allopurinol-induced SJS/TEN, test characteristics, costs, and epidemiologic data for Thailand from a societal perspective. Input data were obtained from the literature and a retrospective database analysis. The results were expressed as incremental cost per QALY gained. A base-case analysis was performed for patients at age 30. A series of sensitivity analyses including scenario, one-way, and probabilistic sensitivity analyses were constructed to explore the robustness of the findings. Based on a hypothetical cohort of 1,000 patients, the incremental total cost was 923,919 THB (USD 29,804) and incremental QALY was 5.89 with an ICER of 156,937.04 THB (USD 5,062) per QALY gained. The cost of gout management, incidence of SJS/TEN, case fatality rate of SJS/TEN, and cost of genetic testing are considered very influential parameters on the cost-effectiveness value of HLA-B*5801 testing.ConclusionsThe genetic testing for HLA-B*5801 before allopurinol administration is considered a highly potential cost-effective intervention in Thailand. The findings are sensitive to a number of factors. In addition to cost-effectiveness findings, consideration of other factors including ethical, legal, and social implications is needed for an informed policy decision making.

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SJS/TEN 2019: From science to translation.

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SJS/TEN 2019: From science to translation.

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