Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort.

ABSTRACT: Transdiagnostic research has identified a general psychopathology factor-often called the 'p' factor-that accounts for shared variation across internalizing, externalizing, and thought disorders in diverse samples. It has been argued that the p factor may reflect dysfunctional thinking present in serious mental illness. In support of this, we previously used a theory-free, data-driven multimodal neuroimaging approach to find that higher p factor scores are associated with structural alterations within a cerebello-thalamo-cortical circuit (CTCC) and visual association cortex, both of which are important for monitoring and coordinating information processing in the service of executive control. Here we attempt to replicate these associations by conducting region-of-interest analyses using da

SUBMITTER: Romer AL 

PROVIDER: S-EPMC7266702 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature