Antinuclear Antibody-Negative Systemic Lupus Erythematosus in an International Inception Cohort.

ABSTRACT:

Objective

The spectrum of antinuclear antibodies (ANAs) is changing to include both nuclear staining as well as cytoplasmic and mitotic cell patterns (CMPs) and accordingly a change is occurring in terminology to anticellular antibodies. This study examined the prevalence of indirect immunofluorescence (IIF) anticellular antibody staining using the Systemic Lupus International Collaborating Clinics inception cohort.

Methods

Anticellular antibodies were detected by IIF on HEp-2000 substrate using the baseline serum. Three serologic subsets were examined: ANA positive (presence of either nuclear or mixed nuclear/CMP staining), anticellular antibody negative (absence of any intracellular staining), and isolated CMP staining. The odds of being anticellular antibody negative vers

SUBMITTER: Choi MY 

PROVIDER: S-EPMC7268889 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature