Dataset Information

Association of Genetic Polymorphisms With Afatinib-induced Diarrhoea.

ABSTRACT:

Background/aim

Afatinib, a 2^nd generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used in treatment of non-small cell lung cancer (NSCLC), causes diarrhoea in over 90% of patients. The association of genetic background with diarrhoea is poorly understood.

Patients and methods

We evaluated the roles of four single nucleotide polymorphisms (SNPs) in ATP binding cassette subfamily B member 1 (ABCB1) and ATP binding cassette subfamily G member 2 (ABCG2) genes-ABCB1 1236 C>T, 2677 G>T/A, and 3435 C>T, and ABCG2 421 C>A-on treatment-induced diarrhoea in 38 patients with NSCLC treated with afatinib.

Results

Diarrhoea occurred more frequently in patients with ABCB1 2677 T(A)/T(A) (14/16, 87.5%) than in patients with non-T(A)/T(A) alleles (8/22, 36.4%) (p=0.003). ABCB1 2677 T(A)/T(A) was significantly predictive of diarrhoea (p=0.002) by multivariable regression analysis.

Conclusion

Afatinib-induced diarrhoea is associated with the SNP ABCB1 2677 T(A)/T(A).

SUBMITTER: Sogawa R

PROVIDER: S-EPMC7279839 | biostudies-literature | 2020 May-Jun

REPOSITORIES: biostudies-literature

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Publications

Association of Genetic Polymorphisms With Afatinib-induced Diarrhoea.

Sogawa Rintaro R Nakashima Chiho C Nakamura Tomomi T Takeuchi Koji K Kimura Sakiko S Komiya Kazutoshi K Narisawa Yutaka Y Kimura Shinya S Sueoka-Aragane Naoko N

In vivo (Athens, Greece) 20200501 3

<h4>Background/aim</h4>Afatinib, a 2<sup>nd</sup> generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used in treatment of non-small cell lung cancer (NSCLC), causes diarrhoea in over 90% of patients. The association of genetic background with diarrhoea is poorly understood.<h4>Patients and methods</h4>We evaluated the roles of four single nucleotide polymorphisms (SNPs) in ATP binding cassette subfamily B member 1 (ABCB1) and ATP binding cassette subfamily G member ...[more]

PMID: 32354939

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Dataset Information

Association of Genetic Polymorphisms With Afatinib-induced Diarrhoea.

Background/aim

Patients and methods

Results

Conclusion

Publications

Association of Genetic Polymorphisms With Afatinib-induced Diarrhoea.

Similar Datasets

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