Whole-genome sequencing of Chinese centenarians reveals important genetic variants in aging WGS of centenarian for genetic analysis of aging.

ABSTRACT:

Background

Genetic research on longevity has provided important insights into the mechanism of aging and aging-related diseases. Pinpointing import genetic variants associated with aging could provide insights for aging research.

Methods

We performed a whole-genome sequencing in 19 centenarians to establish the genetic basis of human longevity.

Results

Using SKAT analysis, we found 41 significantly correlated genes in centenarians as compared to control genomes. Pathway enrichment analysis of these genes showed that immune-related pathways were enriched, suggesting that immune pathways might be critically involved in aging. HLA typing was next performed based on the whole-genome sequencing data obtained. We discovered that several HLA subtypes were significantly overr

SUBMITTER: Shen S 

PROVIDER: S-EPMC7285530 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature