Tuning Cell Motility via Cell Tension with a Mechanochemical Cell Migration Model.

ABSTRACT: Cell migration is orchestrated by a complicated mechanochemical system. However, few cell migration models take into account the coupling between the biochemical network and mechanical factors. Here, we construct a mechanochemical cell migration model to study the cell tension effect on cell migration. Our model incorporates the interactions between Rac-GTP, Rac-GDP, F-actin, myosin, and cell tension, and it is very convenient in capturing the change of cell shape by taking the phase field approach. This model captures the characteristic features of cell polarization, cell shape change, and cell migration modes. It shows that cell tension inhibits migration ability monotonically when cells are applied with persistent external stimuli. On the other hand, if random internal noise is signific

SUBMITTER: Tao K 

PROVIDER: S-EPMC7300309 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature