A novel faecal Lachnoclostridium marker for the non-invasive diagnosis of colorectal adenoma and cancer.

ABSTRACT:

Objective

There is a need for early detection of colorectal cancer (CRC) at precancerous-stage adenoma. Here, we identified novel faecal bacterial markers for diagnosing adenoma.

Design

This study included 1012 subjects (274 CRC, 353 adenoma and 385 controls) from two independent Asian groups. Candidate markers were identified by metagenomics and validated by targeted quantitative PCR.

Results

Metagenomic analysis identified 'm3' from a Lachnoclostridium sp., Fusobacterium nucleatum (Fn) and Clostridium hathewayi (Ch) to be significantly enriched in adenoma. Faecal m3 and Fn were significantly increased from normal to adenoma to CRC (p<0.0001, linear trend by one-way ANOVA) in group I (n=698), which was further c

SUBMITTER: Liang JQ 

PROVIDER: S-EPMC7306980 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature