Histological evaluation of cellular response to a multifilament electrospun suture for tendon repair.

ABSTRACT:

Background

Rotator cuff tendon repair in humans is a commonly performed procedure aimed at restoring the tendon-bone interface. Despite significant innovation of surgical techniques and suture anchor implants, only 60% of repairs heal successfully. One strategy to enhance repair is the use of bioactive sutures that provide the native tendon with biophysical cues for healing. We investigated the tissue response to a multifilament electrospun polydioxanone (PDO) suture in a sheep tendon injury model characterised by a natural history of failure of healing.

Methodology and results

Eight skeletally mature English Mule sheep underwent repair with electrospun sutures. Monofilament sutures were used as a control. Three months after surgery, all tendon repairs healed, without system

SUBMITTER: Rashid M 

PROVIDER: S-EPMC7319602 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature