Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2.

ABSTRACT:

Background

Identifying effective drugs to suppress vascular inflammation is a promising strategy to delay the progression of abdominal aortic aneurysm (AAA). Itaconate has a vital role in regulating inflammatory activation in various inflammatory diseases. However, the role of itaconate in the progression of AAA is unknown. In this study, we explored the inhibitory effect of itaconate on AAA formation and its underlying mechanisms.

Methods

Quantitative PCR, western blotting and immunohistochemistry were used to determine Irg1 and downstream Nrf2 expression in human and mouse AAA samples. Liquid chromatograph-mass spectrometry (LC-MS) analysis was performed to measure the abundance of itaconate. OI treatment and Irg1 knockdown were performed to study the role of OI in AAA for

SUBMITTER: Song H 

PROVIDER: S-EPMC7322255 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature