The trajectory of high sensitivity C-reactive protein is associated with incident diabetes in Chinese adults.

ABSTRACT:

Background

We performed a cohort study to evaluate the association between the CRP trajectory and incident diabetes in Chinese adults.

Methods

Included were 6439 adults (4111 men and 2249 women; aged 46.6 ± 11.9 years). The concentration of high sensitivity CRP (hs-CRP) was measured in 2013 (baseline), 2014, and 2015. The hs-CRP trajectory was identified based the above three measurements by latent mixture modeling. Incident diabetes cases were diagnosed by fasting blood glucose (≥126 mg/dl) or Hb A1c (≥6.5%) during subsequent 3 years (2016-2018).

Results

Hs-CRP concentration during 2013-2015 was classified into 3 levels: low (< 1.0 mg/L), moderate (1.0-3.0 mg/L), and high (≥3.0 mg/L) based on a statement by American Heart Association. We named four hs-CRP trajectorie

SUBMITTER: Xu R 

PROVIDER: S-EPMC7325292 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature