The Superior Ability of Human BDCA3⁺ (CD141⁺) Dendritic Cells (DCs) to Cross-Present Antigens Derived From Necrotic Lung Cancer Cells.

ABSTRACT: Dendritic cells (DCs) play a key role in initiating and regulating the immune responses to pathogens, self-antigens, and cancers. Human blood DCs comprise a family of different subsets: plasmacytoid DCs (pDCs) and CD16⁺, CD1c/BDCA1⁺, and BDCA3⁺ (CD141⁺) myeloid DCs and possess different phenotypes and functional characteristics. Lung cancer is the most common cancer, with the highest morbidity and mortality in the world. However, which DC subset plays a leading role in the lung cancer immune responses is unclear. We reanalyzed C-type lectin domain family 9 member A (CLEC9A) and CD141 (THBD) gene expression profiles from the Cancer Genome Atlas (TCGA) database and performed the Kaplan-Meier survival analysis of overall survival for several cancers

SUBMITTER: Gu FF 

PROVIDER: S-EPMC7325999 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature